Seminarium Wydziałowe 27.11.2024
21 11 2024
Dziekan Wydziału Chemii Uniwersytetu Warszawskiego zaprasza na
SEMINARIUM WYDZIAŁOWE
27 listopada 2024 (środa), o godz. 14:00,
w Sali Starej Biblioteki (I p.)
Prof. MOHAMMED HAWASH
(An-Najah National University, Palestine)
wygłosi wykład
„Benzodioxol Derivatives: A Journey from Synthesis to Therapeutic Breakthroughs”
Serdecznie zapraszam Pracowników, Doktorantów i Studentów Wydziału Chemii, oraz inne zainteresowane osoby.
Prof. dr hab. Sławomir Sęk
Abstract: This lecture delves into the synthesis and therapeutic potential of a novel series of benzodioxol derivatives, showcasing how these compounds could impact multiple biological targets. With a focus on approximately 55 newly synthesized derivatives, the session explores their biological activity through comprehensive in vitro and in vivo assessments, targeting AMPA receptors, COX enzymes, α-amylase, and cancer cell lines. Key highlights include benzodioxol derivatives with potent activity on AMPA receptors, suggesting potential applications in Parkinson’s disease treatment. Additionally, the aryl acetate derivatives in this series exhibit strong selectivity for COX-2 enzymes, indicating promise as non-steroidal anti-inflammatory agents. Certain acetic acid and carboxamide compounds also demonstrate significant α-amylase inhibition, with in vivo results showing superior blood sugar reduction compared to Acarbose.